Intestinal Abnormalities & Surgeries😍

CT Enterography

  • Best for any Small bowel pathology
  • Mannitol is given
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Mesenteric Cyst

  • IOC: CECT.

Tillaux Triad

  1. Periumbilical swelling.
  1. Tillaux sign: Swelling moves at right angle to attachment of mesentery.
  1. Transverse band of resonance.

Line of mesenteric attachment

  • Runs from the duodenojejunal flexure (left of L2 vertebra)
  • To the ileocecal junction (right sacroiliac joint).
  • So, it runs obliquely from left upper abdomen → right lower abdomen

Structures crossed by root of mesentery:

  • 3rd part of duodenum
  • Aorta, IVC
  • Right gonadal vessels,
  • ureter, genitofemoral N
  • Right psoas

Types

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In mesenteritis, ultrasound shows thickened and distorted appearance of the root of mesentery with a halo of sparing surrounding the vessels
Feature
Chylolymphatic Cyst (m/c)
Enterogenous
Tissue
Sequestered lymphatic tissue
Sequestered bowel tissue
Cyst wall
Thin
Thick
Fluid
Clear
Turbid
Blood supply
Independent
Shared with bowel
Rx
Enucleation
Resection & anastomosis

Bowel Obstruction

3 - 6 - 9 Rule

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  • Bone
    • notion image
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  • Bowel obstruction
    • >3 cm dilatation: small bowel obstruction.
    • >6 cm dilatation: colonic obstruction.
    • >9 cm dilatation: caecal obstruction.

Cardinal Features

  • Non passage of flatus & faeces (Obstipation).
  • Distention.
  • Vomiting.
  • Abdominal pain.

Investigations

  1. X-ray abdomen: Erect & supine (Initial Ix).
  1. CECT: IOC in adults.
  1. USG: IOC in children.

X-ray Features

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  • Image A → Incomplete haustrations of colon → large bowel obstruction.
  • Image B → valvulae conniventes of jejunum → small bowel obstruction.

Image C shows multiple air fluid levels

  • Erect X-ray
  • >3 air fluid levels
  • Step ladder pattern
  • indicates small bowel obstruction.
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String of pearl sign: (D)

  • Seen in small bowel obstruction.
  • Air locules arranged one behind another.
  • Dilated bowel pushes air between valvulae conniventes to the periphery.

Supine X-ray

Site of obstruction
Features
Jejunum
Feathery appearance, 
valvulae conniventes
 
(Concertina effect).
Ileum
Featureless
(loops of wangensteen).
Large bowel
Incomplete haustrations.

Management of Bowel Obstruction

  1. NPO.
  1. IV fluids.
  1. IV antibiotics & painkillers.
  1. Ryle's tube insertion.
  1. Sx: Emergency laparotomy.
      • First visualisedCaecum
        • Caecum is distended: Large bowel obstruction.
        • Caecum collapsed: Small bowel obstruction.

Intussusception

Case Scenario: An 11-month-old baby was brought with a history of incessant crying and abnormal stool with blood and mucus. A tender mass is palpable in the right abdominal region. What is the diagnosis?.
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  • M/c: Ileocolic
  • Telescoping of one bowel loop into another.
    • Intussuscipiens: Receiving loop.
    • Intussusceptum: Loop going inside.
    • Narrowest portion → Neck → Obstruction

Definition:

  • When 1 portion of the GI tract is telescoped into another.

Types

Age Group
Primary (6 months - 2 yrs)
Secondary (Adults)
Trigger
Hypertrophy of peyer's patches
2° to pathological lead point:

Polyp (m/c),
Diverticulum,
Cancer.
Features
Ileocolic (m/c).
-
Red currant jelly stools.
-
Sign of dance (Empty RIF) 
(Lump is in lumbar region).
-

Clinical Feature:

  • Severe colicky pain in abdomen +
  • Red currant jelly stools.
    • With pain → Intussusception
    • Without pain → Meckel’s diverticulum
  • Sausage-shaped palpable mass in the abdomen.
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  • Telescoping of bowel loop.
  • M/c in weaning age group.
  • Red currant jelly stools.

Investigations

  1. X-ray abdomen: Erect & supine (Initial).
  1. USG: Target/Donut/Pseudokidney sign.
      • good sensitivity in diagnosis.
      • Note: IOC in children.
      • Note: IOC in adults: CECT.
       

Barium enema sign:

  • Claw sign.
  • Coiled spring sign.
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Colocolic intussusception → Claw sign
Colocolic intussusception → Claw sign

Treatment:

  • Contrast enema: Xray
    • Pincer/claw sign.
    • Diagnostic & therapeutic.
    • C/I:
      • Perforation,
      • recurrence or
      • 2° to pathological lead point.
  • Air enema → Xray
  • Saline enema → USG
  • Spontaneous resolution occurs in 10% of the patients.
  • Hydrostatic reduction under Fluoroscopic or USG guidance.
  • Surgical reduction may be required in:
    • Refractory shock.
    • Suspected intestinal perforation or necrosis.
    • Multiple recurrences or peritonitis.
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  • Pick pocketer () → got coins () with red blood (hematoma) like coiled spring ()

Sigmoid Volvulus

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caecal volvulus
caecal volvulus
Feature
Sigmoid Volvulus
Caecal Volvulus
Large bowel
Dilated
Collapsed
RF
Elderly with constipation
On
antipsychotic meds.
Long & narrow mesentery.
Redundant sigmoid.
Pregnancy
Pelvic Sx
Rotation
Anticlockwise > Clockwise
App
Coffee bean sign/ Omega sign/
bent tube appearance

Barium enema
Bird beak sign/ Bird of prey sign
Embryo sign
Bowels
2 bowel loop
1 bowel loop
Haustrations
Ahaustral
Haustral
Management
Flatus tube/endoscopic detorsion

Def: Sigmoidectomy
Unstable, peritonitis: Hartmann's procedure
Surgery
  • Coffee bean sign/Omega sign
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  • Bird beak sign/ Bird of prey sign
    • on barium enema.
      • notion image

Caecal Volvulus

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  • Haustrations present with single loop.
  • Embryo sign.
 

MIDGUT Volvulus with malrotation

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Conditions
1st R
2nd R
3rd R
Non-Rotation
N
Abnormal
Abnormal
SI on right side
LI on left side
Malrotation
N
N
Absent
• Subpyloric Caecum

Persistence of Ladd band
Duodenal obstruction
Bilious vomiting
Double bubble sign

Very short mesentery
High risk of volvulus
Reverse Rotation
N
180° clockwise
In effect = 90 clockwise
Transverse colon is overlapped by:
Superior mesenteric artery
↳ Duodenum

Cause obstruction
  • CT
    • notion image
 
  • Contrast → Iohexol
    • BARIUM NOT USED
    • Corkscrew appearance
      • Corkscrew appearance
        Corkscrew appearance

Adhesive Intestinal Obstruction

  • m/c cause of small bowel obstruction (Dynamic).

Causes

  1. Post surgery (m/c).
  1. Non-surgical causes:
      • Crohn's disease.
      • PID.
      • TB.
      • Endometriosis.
      • Cancer.

IOC

  • CECT.

Management (Mx)

  • Conservative for 48-72 hours fails → Surgery (Adhesiolysis).

Ladd's Band

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  • m/c intestinal malrotation abnormality.
  • Runs from Rt hypochondrium to caecum.
  • Duodenal compression.
  • Mx: Excision of band.

Intestinal Stricture

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Causes

  1. Cancer.
  1. Post radiotherapy.
  1. TB.
  1. Crohn's disease.

Management (Mx)

  • Strictures are close: Resection & anastomosis.
  • Strictures are farHeinke Mikulicz stricturoplasty.

Ileo Cecal TB

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  • Pulled up caecum.
    • Pulled up contracted caecum (due to fibrosis).
  • String sign:
    • Narrowing of terminal ileum- Stricture.
      • notion image
  • Inverted umbrella sign/ Fleischner sign:
    • widening of ileocecal valve.

Meckel's Diverticulum

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  • Rule of 2s: 
    • 2% of population
    • 2 inches long
    • 2 feet from ileocolic junction.
    • 2 tissues
  • Only True diverticulum: All layers (+).
  • Remnant of vitellointestinal duct.
  • Present along the antimesenteric border.
  • During embryonic development, the diverticulum arises from the same
    embryonic structure as the stomach and pancreas.
    • As a result, gastric mucosa and pancreatic tissue may be present in the diverticulum
  • Independent blood supply: Safe resection possible.
  • Red currant jelly stools.
    • With pain → Intussusception
    • Without pain → Meckel’s diverticulum

Tc99 Pertechnate scan

  • Warthin’s
  • Meckel’s → 2 mucosa → CHORIOSTOMA
    • Scan of choice
    • Detects ectopic gastric tissue
    • Pancreas
    • Stomach
      • notion image
  • Pertechnetate is taken up by:
    • Thyroid
    • Stomach
    • Salivary gland

Thyroid Cancer:

  • Shows decreased uptake (cold nodule)

Salivary gland tumors:

  • Show cold spot

Exception:

  • Warthin's tumourhot spot
  • Focal Nodular Hyperplasia (FNH) → hotspot
  • Warthin → Is on a war → hot
Radioisotope
Key Findings / Notes
Tc99m-MDP
(
methylene diphosphonate)
Bone Scan
Hot Spots: Mets, Bone tumors, Metabolic bone disease.
Cold Spots: Multiple Myeloma.
Tc99m-HIDA
Acute Cholecystitis
Bile leaks: Sensitive (fail to localise the site).
To rule out EHBA
Gold standard: Intra-op Cholangiography.
Tc99m Sestamibi
PTH Adenoma
Tc99m Sulphur colloid scan
Hot Spot
Kupffer cellsFocal Nodular Hyperplasia (FNH)
Sulphur - Kupfer
Tc99m pertechnate
* Meckel's Diverticulum
*
Warthin's tumor
Tc99m DMSA
Static morphology (Scar)
Tc99m DTPA / MAG3
ObStruction → Functional / Dynamic

Vitellointestinal Duct Abnormalities

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  1. Completely patent: Fecal discharge.
  1. Fibrous band formation: Leads to volvulus.
  1. Patent umbilical end: Umbilical cyst/polyp → Purulent discharge.
  1. Ileal end patent: Meckel's diverticulum.

Duodenal Atresia

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Feature
CHPS
Duodenal atresia
At birth
Normal at birth.
Manifest at 2-3 weeks
Manifest at birth
Complaints
Non-bilious projectile vomiting
Bilious vomiting
Seen m/c in
First born male child
Down syndrome
IOC
USG
X-ray >>USG > CECT
(Double bubble appearance)
Mx
Ramstedt pyloromyotomy
Diamond Duodenoduodenostomy

Bubble sign:

  • Single bubble sign:
    • Pyloric stenosis.
    • notion image
  • Triple bubble sign:
    • Jejunal atresia.
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  • Double bubble sign:
      1. Duodenal atresia.
          • Bilious vomiting.
          • Presents immediately after birth.
      1. Annular pancreas
          • with non bilious vomiting
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  • Multiple bubble sign:
    • Ileal atresia.
    • notion image
  • Common in Down's syndrome.
  • C/F: Bilious vomiting since birth.
  • D/D: CHPS.
  • X-ray: Double bubble sign.
    • Also seen in annular pancreas with non bilious vomiting
  • Mx: Duodenoduodenostomy.

Jejunal Atresia

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  • X-ray: Triple bubble sign
  • Next: Gastrograffin follow through
    • To differentiate between Hirschsprung and Jejunal atresia
Mnemonic
S: Stomach
D: Duodenum
T: Jejunum

Appendicitis

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Note

  • Taenia coli are absent in:
    • Appendix
    • Caecum
    • Rectum
  • Appendices epiploicae are absent in:
    • Appendix
    • Rectum
  • Appendix lacks:
    • Taenia coli (Sacculations)
    • Appendix epiploicae
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Surgical Anatomy

  • Appendicular artery:
    • Branch of lower division of ileocolic artery.
  • Appendicular base:
    • Junction of 3 taenia coli.

Positions

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Blood Supply

  • Appendicular artery (end artery).

Nerve Supply

  • Parasympathetic fibres: Vagus nerve.
  • Sympathetic fibres: T₁₀ - T₁₁ fibres.
    • T₁₀ fibres also innervate umbilicus (present at L₃-L₄ level).
    • Therefore in any Midgut Pathology
      • Pain referred to umbilicus.
  • Retrocaecal (m/c) : 74%
  • Pelvic : 21%
  • Subcaecal : 1.5%
  • Post-ileal : 0.5%
  • Pre-ileal : 1%
  • Paracaecal : 2%
    • L/c: most difficult to diagnose.

Symptoms

  1. Pain abdomen.
  1. Nausea & vomiting (m/c).
  1. Anorexia.
  1. Fever.

Signs

  • McBurney's point tenderness.
    • notion image
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Sign
Pain on
Rovsing sign
RIF on pressing LIF
Sing when pressing
Acute appendicitis
Dunphy's sign
Coughing
Dump people cough
Acute appendicitis
Psoas sign
RIF on flexion against resistance
Psoas →So much Flexing
Rertroceacal appendicitis
Obturator sign
Flexion + internal rotation of hip
Obturator → Old Granny → Internal rotation
Also in Obturator hernia
Pelvic appendicitis

Modified Alvarado (MANTRELS) Score

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  • Score >7: Likely appendicitis.
  • Mnemonic: Two → Tenderness → Total count

Investigations

  • 1st investigation: USG.
  • Best investigation: CECT (visualizes retrocecal appendix).
  • Distended appendix >6mm with surrounding fluid.
  • Inflamed appendix is non compressible.
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  1. CECT: IOC in adults.
      • CECAL BAR SIGN
      • ARROW HEAD SIGN
  1. USG: IOC in children.
      • Blind ending tubular structure.
      • Probe tenderness.
      • Periappendiceal fluid collection.

Management (Appendicectomy)

A → Grid Iron → splitting
B → Lanz → splitting
C →Rutherford Morrison → cutting
A → Grid Iron → splitting
B → Lanz →
splitting
C →Rutherford Morrison →
cutting
Identify the incision
Identify the incision
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  • Appendicitis → Appendicectomy → No need to bury the base
  • Inflamed base → Dont crush the base → Bury with purse string suture
  • Gangrenous base /caecal wall gangrene → Right hemicolectomy.
  • Appendix not inflamed Rule out Meckel's diverticulum (Distal 2 feet of ileum).

Incisions Used

  1. McBurney's incision:
      • grid iron:
        • muscle splitting.
      • Rutherford morrison:
        • muscle cutting.
  1. Lanz/skin crease/bikini incision:
      • Better cosmesis.
      • muscle splitting
  1. Lower midline abdominal incision: For perforated appendix.
    1. notion image
  1. Gibson's incision
      • Above inguinal ligament (→ E)
      • To identify ureter (for Renal transplant).
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Structures Passed (for Lap. appendicectomy incisions)

  1. Skin.
  1. Superficial Fascia.
  1. External oblique aponeurosis.
  1. Muscles.
  1. Peritoneum.

Complications

  1. Wound infection (m/c).
  1. Bleeding.
  1. Portal pyemia.
  1. Stump appendicitis (If stump > 4mm).

Appendicitis in Pregnancy

  • m/c non obstetrical emergency.
  • C/F: Pain in RIF (Can be higher up also).
  • Lx: USG, if unconfirmed → MRI.
  • Mx: Lap. appendicectomy in all trimesters.
    • D/t ↑ Risk of preterm labor/abortions.

Yersinia enterocolitica

  • Causes inflammation of:
    • Terminal ileum
    • Appendix
    • Cecum
    • Mesenteric lymphadenopathy
  • Most Common differential diagnosis of acute appendicitis

Acute Mesenteric Lymphadenitis

  • Mimics acute appendicitis
  • Presents with:
    • Acute right lower quadrant abdominal pain
    • Enlarged mesenteric lymph nodes
    • Normal appendix
  • Diagnosis:
    • Made during abdominal exploration
    • Reveals normal appendix with enlarged mesenteric lymph nodes
  • Common in:
    • Children
    • Young adults

Appendicular Perforation

  • Omentum dysfunction.
  • Seen in:
    • Children.
    • Elderly.
    • Adhesions.
    • Pregnant females.
    • Immunocompromised patients.
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Appendicular Lump

  • Mx:
    • Ochsner-Sherren regime (Conservative).
    • Mnemonic: Sherin nte appendix lu ochu

Management and Outcomes

  • Monitor:
    • Size of lump.
    • Tenderness.
    • Temperature.
    • Pulse rate.
  • Rx:
    • NPO.
    • IV fluids.
    • IV antibiotics.
    • Analgesics.
  • Outcomes:
    • Recovers:
      • Discharge.
      • Interval appendicectomy after 6 weeks.
    • Deteriorates (↑ Pain, fever & lump size):
      • Suspect abscess.
      • Extraperitoneal drainage (Pigtail catheter).

Diverticular Disease

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Diverticulosis

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  • m/c Site: Sigmoid colon
  • Asymptomatic diverticuli.
  • Type: False diverticula (mucosal herniation)
  • Formation: Along mesenteric border
    • NOTE: Meckel's → True diverticula → Anti mesenteric border
  • Demographics: 4th – 5th decade
  • Association: Constipation
  • m/c Cause of: Massive lower GI hemorrhage
  • IOC-Barium enema.
    • Saw tooth appearance.
    • notion image

Diverticulitis

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  • Left side (Sigmoid colon) > Right side

Complications of Diverticular Disease

  • Bleeding: Right > Left (SMA > IMA distribution)
  • Diverticulitis
  • Colorectal cancers (potential long-term link)

Clinical Features of Diverticulitis

  • Left lower quadrant pain
  • Diarrhea
  • Fever
  • Raised TLC (Total Leukocyte Count)

Radiology

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  • Inflammation of diverticulum.
  • Patient presents with pain.
  • IOC-CECT.
  • Hinchey's classification.
 

Hinchey Staging System (Based on CECT - IOC)

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  • Stage I: Colonic inflammation with pericolic abscess
    • 1a → Pericolonic Phlegmon and inflammation
    • 1b Pericolonic abscess <4cm
  • Stage II: Colonic inflammation with pelvic abscess
  • Stage III: Purulent peritonitis
  • Stage IV: Fecal peritonitis
    • Mnemonic: DaVinci → Dive Hinchey → Abcess→ PP → FP

Management by Stage:

  • Stage I & II: Pigtail catheter drainage (for abscess).
  • Stage III & IV: Laparotomy + Hartmann procedure (colostomy)

Imaging Note on Diverticular Disease

  • Barium enema/colonoscopy is avoided
    • ↑↑ increased risk of perforation during acute diverticulitis.

Angiodysplasia

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Features & Clinical Aspects

  • 2nd m/c Cause of: Lower GI bleed
  • Pathology: Dilated arterioles
  • m/c Site: Cecum
  • Demographics: Seen in elderly (5th – 6th decade)
  • Heyde Syndrome: Angiodysplasia + Aortic stenosis

Management

  • Investigation: Colonoscopy, Capsule endoscopy
  • Treatment: Coagulation/cauterization

Ileostomy

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Feature
Ileostomy
Colostomy
Output
More, liquid
Less, semi-solid
Skin Excoriation
More risk
Less risk
Fluid & Electrolyte Imbalance
More risk
Less risk
Ease of Management
Less easy
Easier
Technical Difference
Raised above the skin (pouting)
Flat (same level as skin)

Types of Stoma

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End Stoma

  • One bowel end brought out.

Double Barrel Stoma

  • Two bowel ends brought out.
  • Not joined to each other.

Loop Stoma

  • Two bowel ends brought out.
  • Are joined (often a loop over a rod).

Complications of Stoma

  • NecrosisEarliest complication
  • Skin Excoriation: m/c complication
  • Parastomal Herniationm/c long-term complication
  • Fluid & electrolyte imbalance
  • Bowel obstruction
  • Prolapse
  • Retraction

Short Bowel Syndrome (SBS)

Definition

  • <200 cm of small intestine remaining.
  • Net Secretors<100 cm of SI.
  • Net Absorbers>100 cm of SI.
  • Prognosis: Good if ileocaecal junction is saved.

Causes

  • MCC CHILDNEC/ Jejunal atresia
  • MCC ADULTCrohn's disease (m/c) > Mesenteric Ischemia
  • Superior mesenteric artery (SMA) syndrome
  • Trauma

Clinical Features

  • Malabsorption
  • Diarrhea
  • Weight loss
  • Bacterial overgrowth

Management

  • TPN (Total Parenteral Nutrition)
  • Small intestine transplantation
  • Teduglutide (GLP2 analogue)

Bowel Lengthening Procedures

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  • Bianchi procedure, Kimura procedure
    • B (Bowel) anch (Bianchi) thavana valikkum → to lengthen
  • STEP (Serial Transverse Enteroplasty)

Faecal Fistulae

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  • Take a SNAP (SNAP protocol) of feces from abdomen guys

Factors Favoring Spontaneous Closure

  • Origin:
    • Esophageal
    • Duodenal
    • Jejunal stump
  • Enteric Wall Defect: <1 cm
  • Fistula Tract Length: >2 cm
  • No abdominal wall defect
  • Good Nutrition: Albumin >2.5 g/L
  • Low Output Fistula: <200 mL/day

No F.R.I.E.N.D Factors (Factors Preventing Closure):

  • Foreign body
  • Radiation
  • Inflammation, Infection, IBD
  • Epithelialization of fistula tract
  • Neoplasm
  • Distal obstruction

Fistula Output

  • High Output Fistula: >500 mL/day

Management

Spontaneous Closure Likely

  • Conservative management

Spontaneous Closure Unlikely
SNAP ProtocolEnterocutaneous fistula

  • Skin care, Sepsis control
  • Nutrition
  • Anatomical delineation (imaging)
  • Planned surgery

Prognostic Grouping of Fistula

Feature
I
II
III
Degree of complexity of fistula
Low
Intermediate
High
Mortality
Low
10 - 25%
>25%
Rx goals
Spontaneous closure
Early surgical closure
Late surgical closure

Notes

  • Metabolic derangements in fecal fistula:
    • Fluid + electrolyte imbalance.
  • Maximum output (fluid and electrolyte output)
    • pancreatic and biliary fistula:
      • Opening in Duodenum > Jejunum
      • Opening after pancreatic and biliary juices.
  1. What is the primary cause of severe malnutrition among the options provided below?
    A. Pancreatic fistula
    B. Duodenal fistula
    C. Distal ileal fistula
    D. Colonic fistula
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Laparoscopy

  • Minimally Invasive Surgery.

Pneumoperitoneum:

  • Gas: CO2 (Non-combustible).
  • Pressure: 10-14 mmHg.
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  • Air in peritoneal cavity due to ruptured hollow viscus organ (perforation, post laparoscopy).
  • On CT, jet black appearance shows air.


Physiological Effects:

  • Sinus Bradycardia: 
    • M/c arrhythmia in laparoscopy
    • Due to peritoneal stretching → Vagal stimulation
  • Decreased SBP, CO, Reflex tachycardia
    • Due to IVC compression.
  • Increased Airway resistance & Positive End-Expiratory Pressure (PEEP): 
    • As diaphragm is pushed up, decreasing thoracic volume.
    • So use with caution in COPD
  • Decreased Urine output
    • Due to compression of renal artery.
  • Increased Intracranial pressure.
Angle
Definition
Minimum angle
Manipulation angle
• Between two working ports
60°
Azimuth angle
• Between camera port and working port
Camerayil kude working nokkunna muth
30°
Elevation angle
• Between working port and horizontal line
• Hosrizontally kidakkumbo work by elevation
60°
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Instruments:

  • Veress Needle: 
    • Used in closed method to create pneumoperitoneum,
    • has a beveled edge.
    • Involves blind puncture of peritoneum
    • notion image
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  • Sharp Trocar:
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    • Inserted after Veress needle, used to insert other instruments.
      • If bowel injury:
        • Keep in place & convert to open procedure.
  • Hasson’s Cannula:
    • For open method.
      • notion image
  • Optiport/Visiport: 
    • notion image
    • Transparent end, can hold camera, clear ends.
    • Prevent bowel injury
  • Laparoscopic Instruments:
    • notion image
    • Has insulation (black coating).
    • If insulation breaksCapacitance coupling Bowel injury (burns).
      • Prevention: Plastic trocar.

Other Minimally Invasive Procedures:

SILS (Single Incision Laparoscopic Surgery):

  • Multiple instruments can be inserted from a single port.
    • notion image

Robotic Surgery (Da Vinci System):

  • Advantages:
    • Finer dissection.
    • Better movement (7 degrees of freedom).
    • Tremor reduction.
  • Disadvantages:
    • Expensive.
    • Loss of tactile feedback.

NOTES (Natural Orifice Transluminal Endoscopic Surgery):

  • Scarless
  • Examples:
    • Per-oral Endoscopic Myotomy (POEM).
    • Transanal Total Mesorectal Excision (TATME).
    • Transoral Gastroplasty (TOGA).

Ischaemic colitis:

  • On X-ray:
    • Colonic loops have thick, edematous haustrations
      • Thumbprint sign.
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Pseudomembranous Colitis:

Microscopy: Volcano eruption appearance
Microscopy: Volcano eruption appearance
Pseudomembranes
Pseudomembranes
 
  • It is a type of superinfection.m
  • MC bacteria involved: Clostridium difficile.
  • Cause:
    • Long-term use of antibiotics.
    • Alters gut flora.
  • Clinical features: Watery diarrhoea.
  • Diagnosis:
    • Toxigenic culture: Culture media: 100% sensitivity
      • Cefoxitin cycloserine fructose agar (CCFA).
      • Cefoxitin cysteine yeast extract agar (CCYA).
    • Detection of toxins via ELISA and PCR.
  • MC antimicrobials implicated are:
    • 3rd Gen. Cephalosporins > Clindamycin > Ampi or Amoxycillin > FQ.
  • Accordion sign Thick edematous bowel.
    • notion image
  • Treatment:
    • notion image
    • DOC :
      • Oral Fidaxomicin (Low chances of relapse).
    • Alternative :
      • Oral vancomycin
      • Oral Metronidazole.
    • Monoclonal Ab against toxin :
      • Bezlotoxumab.