PIK3CA Mutation Testing
- Predicts response to Alpelisib (PI3K inhibitor) in HR+/HER2– advanced breast cancer
- Pick me from ER with Alpenlibe
Suzetrigine
- Non opioid drug for moderate to severe pain
- Teprotumumab
- FDA recently approved
- Insulin-like growth factor-1 receptor (IGF-1R) inhibitor
- first drug approved for treatment of adults with thyroid eye disease.
Drug | Target | Use |
Rituximab | CD20 | Relapsed indolent lymphoma, DLBCL |
Ipilimumab | CTLA-4 ⛔ [cytotoxic T lymphocyte-Associated Protein-4] | Late-stage melanoma |
Trastuzumab | HER2 | HER2+ breast & gastric cancer |
Pembrolizumab | PD-1 (Programmed cell death protein 1) | Advanced melanoma, MSI-H / MMR-deficient cancers |
- Loperamide
- DOC in IBS - Diarrhea
- u Agonist:
- Don't cross BBB → Efflux by P-glycoprotein (MDR1 transporter) → No dependence
Drug | Indication | ㅤ |
Plecanatide | Chronic Idiopathic Constipation (CIC) in adult | Pling → when constipated |
Naldemedine | Opioid-induced constipation | Naltrexone → Opioid Similarly → Naldemedine |
Tenapanor | Irritable bowel syndrome with constipation | Thampanoor poyapo IBS vannu |
Telotristat | Severe diarrhea due to Carcinoid tumors | Tell to start the car (Telotristat → Carcinoid) |
4. Omalizumab
- Monoclonal antibody against IgE
- Used for
- Urticaria
- prophylaxis of severe persistent Bronchial asthma
- Not effective in atopic dermatitis
- Given subcutaneously
- Kochinu asthma (asthma) vannapo maran Om Kreem (Om) kuttichathaennu prnj ammumma
5. Anti Interleukins
- In severe eosinophilic BA
- Anti-IL-5:
- Reslizumab
- Mepolizumab
- Mnemonic: Me poli Rasam → 5 benz rally (benralizumab) cheyyum
- Anti-IL-5 Receptor (IL-5R):
- Benralizumab
- Anti-IL-4 Receptor (IL-4R):
- Dupilumab
- out of 5 infront of reception, 4 are duplicate
- IL-13 inhibitor:
- Tralokinumab,
- Lebrikizumab
New drugs COPD :
- Roflumilast : PDE4 ⛔
- Ensifentrine : Both PDE3 ⛔ and PDE4 ⛔
- Rough (Roflumilast) Siphon (Ensifen)
- Phosphodiesterase-5 inhibitors (PDE-5 inhibitors)
- Nitric oxide enhancers.
- Facilitates blood flow into the penis, enhances erection.
- Drugs: Sildenafil, Tadalafil, Vardenafil, Avanafil.
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