Cranial Nerve Nuclei and coloumns😍

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  • Mnemonic:
    • General science → save → gave
  • GSE → General science → eye and tongue
    • 3, 4 (GS → kollilla) → 6 (kollilla) → 12 clasees
  • SVE → Save → Laugh and eat Na (NUcleus Ambigus)
    • 0 → 7 → 9, 10, 11
  • GVE → Gave → smooth action
    • Edi (EW) → thuppi (SS, IS) → Vaninte door (Dorsal vagus) adach
  • GVA, SVA → General Visceral sensations → Track (Nucleus Tractus solitarius) Viscera
  • GSA → Giant SAAr → Big body (body wall)
    • Mesayulla (Mesencephalic) Principal (Principal) with Spine (Spinal nuclei) → We Tried (Trigeminal)
  • SSA → Sixth sense → All senses → vision, hearing, olfaction, balance
    • But I have one to (1, 2 CN) 8 (8 CN) senses
  • Column for 3rd CN
    • GSE & GVE
  • Column for 7, 9 ,10
    • All except 1st and last
  • NTS = Nine, Ten, Seven
  • SVA → Svad → 7, 8, 10
    • Medial → Lateral

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  • Ipsilateral Bulbar Palsy
    • Injury to Nucleus Ambiguus (LMN Lesion)
    • Features
      • (tongue spared)
      • Dysphagia
      • Dysarthria
      • Nasal speech
      • Loss of GAG reflex
      • High risk of aspiration
      • Wasting & fasciculations of palate/pharynx
Region
Location
Structures
Nucleus
Vision
Midbrain
Oculomotor Nerve,
Superior Colliculus
Edinger–Westphal (EW) nucleus
Pharynx & Larynx
Medulla
Cranial nerves 9, 10, 11
Nucleus Ambiguus
Full Form
GVA
General Visceral Afferent
SVA
Somatic Visceral Afferent
GSA
General Somatic Afferent
Gen sensation of face
SSA
Special Somatic Afferent
Full Form
GSE
General Somatic Efferent
SVE
Special Visceral Efferent
Muscles of mastication
Save to eat
GVE
General Visceral Efferent
Nuclei
Full Form
SSN
Superior Salivatory Nucleus
ISN
Inferior Salivatory Nucleus
NTS
Nucleus Tractus Solitarius

Parasympathetic ganglion & Trigeminal Nuclei

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  • Everything is NCC
GVE
Nerve
Ganglion
Postganglionic fibers
(branches of CN V)
Supply
EW
3
Ciliary
Sphincter pupillae &
Ciliaris muscle
SSN
7 →
Via greater petrosal nerve
Pterygopalatine
"Ganglion of Hay Fever"
Maxillary N
(
Zygomatic branch)
Lacrimal gland
SSN
7 →
Via chorda tympani
Submandibular
Lingual N
Submandibular &
Sublingual gland
ISN
9 →
Via lesser petrosal fibers
Otic
Auriculotemporal N
Parotid
Dorsal nucleus
of X
10
Smooth muscles &
glands of thorax & abdomen
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  • Nerves whose general‐sensory fibers enter trigeminal nucleus
    • Arnold’s nerve
    • Glossopharyngeal nerve (proprioception from stylopharyngeus)
  • Short ciliary nerves from ciliary ganglion supply:
    • Sphincter pupillae - constriction of pupil.
    • Ciliaris muscle - accommodation reflex.
  • Important Point
    • CN 7 pierces parotid gland
      • But does NOT provide secretomotor supply to it
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  • Parasympathetic Outflow
    • Cranio-sacral outflow
    • Also Involves Sacral nerves (S2, S3, S4)
  • Sympathetic outflow:
    • Thoracolumbar (T1 to L2)

Trigeminal Nuclei → 3 Parts

a. Motor Nucleus of Trigeminal Nuclei (Pons)

  • Supplies muscles of mastication
  • SVE fibers (from 1st pharyngeal arch)

b. Sensory Nuclei

Pseudo Meesa → Jaw near Meesa
Pseudo Meesa → Jaw near Meesa
Part
Location
Function
1. Mesencephalic
Midbrain
Proprioception from face
Mediates jaw reflex, mastication, EOM, tongue
Only site in CNS containing pseudo-unipolar neurons
↳ Contains primary sensory neuron cell bodies(unique in CNS)
Dorsal coloumn?
Mesa vach door thorannu
2. Principal Sensory
Pons
Touch & pressure sensation from face
Anterior STT?
Principal Aunty
3. Spinal Nucleus
Medulla
Pain & temperature from face
Onion-skin pattern of facial sensory loss

Lateral STT?
Lateral spine
  • Pars caudalis = main pain nucleus of trigeminal system.
  • Reflex intact even in trigeminal neuralgia
    • d/t intact Mesencephalic nucleus
  • Muscle responsible for jaw jerk reflex
    • Masseter (afferent & efferent via trigeminal)

Trigeminothalamic Pathway

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  • 5th Nuclei Ganglion
  • Trigeminal Lemniscus (1st Order Neuron)
  • Thalamus (VPM Nucleus)
    • Relays signals to the Sensory Cortex [3, 1, 2].
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  • Branches of Maxillary Nerve (V2) :
    • Zygomaticotemporal Nerve
    • Infraorbital Nerve
      • Gives rise to alveolar branches
    • Posterior Superior Alveolar Nerve
Alveolar Nerve Branches
Branch of
Supplies
Posterior Superior Alveolar Nerve (PSAN)
Direct branch of Maxillary Nerve
Posterior maxillary teeth
Middle Superior Alveolar Nerve (MSAN)
Branch of Infraorbital Nerve
Middle part of maxillary sinus
and associated teeth
Anterior Superior Alveolar Nerve (ASAN)
Branch of Infraorbital Nerve
Anterior maxillary teeth

Sensory Tracts and Functions

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  • MTSL → Manage 3rd stage Labor
Sensory Tract
Carries C/L
Lateral Lemniscus
Hearing sensation
Spinal Lemniscus
Pain and temperature from body
Trigeminal Lemniscus
Pain and temperature from face
Medial Lemniscus
(Anterior STT & DCT)
- Pressure & crude touch
-
Conscious proprioception
-
Fine touch
- Vibration
-
Stereognosis

CRANIAL NERVE RULES

Rule of 4

  • Midbrain: CN 1, 2, 3, 4
  • Pons: CN 5, 6, 7, 8
  • Medulla: CN 9, 10, 11, 12

Rule of 12

  • Medial CN: 3, 4, 6, 12
  • Affects tongue

Rule of S

  • Side:
      1. Sensory → 5th CN, 7, 8 (pain, temp, etc.)
      1. Sympathetic Horner’s
      1. Spinothalamic tract
      1. Spinocerebellar tract

Rule of M

  • Medial:
      1. Motor CN - 3, 6, 12
      1. Corticospinal Tract (motor)
          • Causes hemiplegia
      1. Medial lemniscus exception
          • Not motor (dorsal column vibration, fine touch)

Reflexes

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Rule of 17: Nerve Lesions and Deviations

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Lesion: (Cranial Nerves 10 + 7 = 17)

  • Deviation: Contralateral deviation (opposite side).
  • Right X → Vagus
    • Deviation of uvula to the left.
  • Right VII → Facial
    • Deviation of facial muscles to the left.

Lesion: (Cranial Nerves 12 + 5 = 17)

  • Deviation: Ipsilateral deviation (same side).
  • Left XII → Hypoglossal
    • On protrusion, tongue deviates to the left.
  • Left V → Trigeminal
    • Deviation of jaw to the left.

Identification of Cranial Nerves

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Identification of Cranial Nerves With Dura Mater Intact

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Cranial Nerve - V

  • Mixed Nerve
    • V1 Sensory
    • V2 Sensory
    • V3 mixed
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  • Divides into 3 branches
      1. Ophthalmic
      1. Maxillary
      1. Mandibular
  • SVE → muscles of Mastication
  • GSA → General sensation from face.

Ophthalmic Nerve (V1)

  • Superior Orbital Fissure (SOF)
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Frontal Nerve

  • Supplies forehead skin.
  • Branches:
    • Supratrochlear nerve
    • Supraorbital nerve

Nasociliary Nerve

  • Branches:
    • Anterior ethmoidal nerve
      • Supplies dura mater of anterior cranial fossa.
      • Goes to nasal cavity.
      • Supplies ethmoidal and sphenoidal air sinus, nasal mucosa.
      • Exits as external nasal branch.
      • Supplies skin over the tip of the nose.
    • Posterior ethmoidal nerve

Lacrimal Nerve

  • Supplies the lacrimal gland.

Trigeminal Nerve

Branches from Trunk

  • Nerve to medial pterygoid
    • Supplies:
      • Medial pterygoid (muscle of mastication)
      • Tensor veli palatini
      • Tensor tympani
    • Only muscle of mastication supplied by trunk (others by anterior division)
  • Nervus spinosus
    • Passes through foramen spinosum
    • Supplies dura mater along with middle meningeal artery (MMA)
      • MMA + Nervus Spinosum = form major neurovascular supply to dura mater

Relations of otic ganglion

  • Topographical relation with V₃
  • Mandelu Otta
  • No synapse occurs here
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Relations
Muscle
Anterior
Medial Pterygoid
Posterior
MMA
Lateral
V3 Nerve/ Mandibular N
Medial
TVP
Roof
Foramen ovale
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Topographic nerve

  • Trigeminal nerve (V)
  • All ganglia are topographically connected to trigeminal nerve
  • Carries postganglionic fibres in parasympathetic pathway

Roots of Otic Ganglion

  • Parasympathetic (secretomotor root)
    • From glossopharyngeal nerve (CN IX) via lesser petrosal nerve
    • Relay in otic ganglion
    • Postganglionic fibers travel with auriculotemporal nerve (branch of V3)
      • Auriculotemporal nerve (V3) pass through without relay
    • Supply parotid gland
  • Sympathetic root
    • From plexus around middle meningeal artery
      • postganglionic fibers from superior cervical ganglion
    • Pass through ganglion without synapse
    • Vasomotor to parotid gland

Mandibular Nerve (CN V₃)

  • Mixed nerve
  • Derived from 1st pharyngeal arch
  • Largest and thickest branch of trigeminal nerve
  • Root value: C₅, C₆, C₇, C₈, T₁
  • Passes through foramen ovale (both sensory & motor components).
  • All muscles supplied by V3 except
    • Medial PterygoidMain trunk of 5th CN
  • Mneumonic:
    • Mandi (Mandibular) aytttulla oru auntie (Anterior ) always chew (mastication) → Was post (Posterior ) and sensitive (Sensory)
    • She had a good aura (Auriculotemporal nerve) and good tongue (Lingual nerve) , but no lower teeth (Inferior alveolar nerve)

Divisions of Mandibular Nerve

  • After passing through otic ganglion:
    • Anterior division
    • Posterior division
Anterior Division
(Motor>Sensory)
Motor (SVE)
Muscle supplied
Masseteric nerve
Masseter
Deep temporal nerves
Temporalis
Nerve to lateral pterygoid
Lateral pterygoid
Sensory (GSA)
Buccal Nerve
Pierces buccinator muscle [Does NOT supply]

Supplies:
Skin of cheek
Mucosa of cheek
Posterior Division
(Mostly Sensory)
Lingual Nerve
Sensory
• GS to
anterior 2/3 of tongue

Parasympathetic Post ganglionic
from submandibular ganglion
↳ to Submandibular & sublingual gland

M/c injured during Wharton’s/submandibular duct surgery.
Inferior alveolar nerve
• Nerve to mylohyoidMylohyoid + Anterior belly of digastric
Mental nerve Skin of chin
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NOTE

Structure
Pierced by but not supplied by
Supplied by
Buccinator
Buccal N (branch of V3)
Buccal branch of facial nervemotor
Parotid
Facial nerve
Auriculotemporal N

NOTE: Referred Otalgia

Lesion Site
Nerve involved in referred pain
Oral lesions /dental caries
5th nerve (V3)
Oropharyngeal lesions / Tonsil
9th nerve (Glossopharyngeal)
Hypopharyngeal & Laryngeal lesions
10th nerve (Vagus)

Inferior Alveolar artery

  • Runs with the inferior alveolar nerve to supply the lower teeth.
  • Gives off:
    • Mental Artery: Exits through the mental foramen to supply the chin.
    • Mylohyoid branch: Supplies the mylohyoid muscle.
  • Mnemonic: Use lower teeth () when Myran (Mylohyoid A) becomes mental (Mental A)
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Structures Piercing Buccinator

  1. Stenson's Duct / Parotid duct
  1. Buccal br. Of Mandibular (V3) NV
  1. Mucus glands of buccopharyngeal Fascia

NOTE

  • Facial N supplies but does not pierce

Clinical Associations:

Trismus (Lockjaw)

  • Silent trismusMedial pterygoid
  • Trismus while yawning/opening mouthLateral pterygoid

Frey’s Syndrome:

  • Gustatory sweating.
  • Parasympathetic fibers of Parotid gland (ATN)
    • communicates with GAN (most common)
  • Stimulus to ATN → sweating in parotid region
  • Investigation: Starch iodine test.
    • Sprinkle starch and Paint iodine
  • ATN fuses with:
    • Ettan (Atn) likes gan
    • GAN > Buccal nerve > Lesser occipital nerve
  • Mx:
    • First line: Botox and anti-perspirants
    • TOC: Tympanic neurectomy.
  • Prevention: 
    • SCM flap/digastric muscle flap to cover parotid bed.
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Identify → Important
Identify → Important

Facial Synkinesis

  • Facial nerve anomalous regeneration
  • Examples
    • Crocodile tears (Bogorad syndrome):
      • Facial N Injury before geniculate ganglion.
      • Fibers anastomose with chorda tympani.
      • Lacrimation when patient eats.
    • Mouth retraction on eye closure
      • orbicularis oculi aberrantly innervate orbicularis oris

Mandibular Foramen

  • Transmits:
    • Inferior alveolar nerve
    • Inferior alveolar vessels

Clinical Testing – CN V₃ Motor

  • Jaw deviation = test of mandibular nerve motor function

Muscles of Mastication (All by CN V₃)

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Primary Muscles
Insertion
Notes
Temporalis
Coronoid process of mandible
• Elevation > Retraction
Masseter
Outer surface of ramus of mandible
Elevation
Strongest muscle of mastication
Best muscle for elevation
Medial Pterygoid
Inner surface of ramus of mandible
Elevation > Protrusion
Only muscle supplied by trunk of CN V₃
Lateral Pterygoid
Capsule of TMJ
Depression > Protrusion
Only depressing muscle of mastication
  • NOTE: Medial pterygoid plate : Doesn't give origin to pterygoid muscles.
  • Protrusion
    • Lateral > medial pterygoid
    • Most apt answer is both
    • Mnemonic: Teri (Both pterygoids) parayan jaw Protrude ()
  • Opening the jaw/ depression of the mandible
    • Lateral pterygoid muscle
    • Remaining 3 muscles: Elevation of mandible
      • Masseter > Temporalis & Medial pterygoid
  • Side movement
    • Alternate action of Lateral & Medial Pterygoids

Facial Nerve (Cranial Nerve 7)

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  • 7th cranial nerve.

Basic Features

  • Mixed nerve
    • Sensory root (nerve of Wrisberg).
    • Motor root.
    • Secretomotor root.
  • Derived from the 2nd pharyngeal arch
  • Exits from pons.

Nuclei

  • Located in the pons
  • Facial motor nucleus
    • deep to the floor of the fourth ventricle
  • Supranuclear palsy:
    • UMN
    • Lesion above pons.
    • Forehead spared
      • Innervation from bilateral cerebral cortex.
  • Infranuclear palsy:
    • LMN
    • Lesion below pons.

Components and Functions

Col.
Nucleus
Function
SVE
Facial motor nucleus in pons
Muscles from 2nd pharyngeal archfacial expression
GVE
SSN
Parasympathetic to submandibular, sublingual, and lacrimal glands
SVA
NTS
Taste from anterior 2/3 of tongue
(via chorda tympani)
GVA
NTS
General visceral sensation
GSA
Trigeminal sensory nucleus
Sensation from auricle, nasal, lacrimal regions

Course and Exit

  • Loops around abducent nucleus forming internal genu
    • elevation in floor of 4th ventricle = Facial colliculus
  • Exits brainstem at pontomedullary junction
  • Enters internal acoustic meatus
  • Longest interosseous course
  • Exits skull via stylomastoid foramen

Course has 3 parts:

  • Intracranial.
  • Intratemporal.
  • Extracranial.

Intracranial route:

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  • Exits nucleus.
  • Turns around 6th nerve nucleusFacial Colliculus
  • Enters internal auditory canal.

Intratemporal route:

  • Longest portion.
  • Runs in bony canal (Fallopian canal).
    • Absent in 50% of population.
  • Most common dehiscence site:
    • horizontal part.

Segments:

Meatal Segment (8–10mm):

  • In internal acoustic meatus.
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  • Falciform crest:
    • vertical Y-shaped crest.
  • Bills bar:
    • crest of bone.
Meatal component → Fallopian canal
Meatal component → Fallopian canal
Quadrant of Internal Acoustic Meatus
Nerve Present
Anterosuperior
Facial nerve
Anteroinferior
Cochlear nerve
Posterosuperior
Superior vestibular nerve
Posteroinferior
Inferior vestibular nerve

Labyrinthine segment:

  • Travels above vestibule.
  • Anterior: Cochlea.
  • Posterior: Semicircular canals.
  • Shortest and narrowest segment.
  • Most prone to ischemia and edema [Bell’s Palsy]

Tympanic segment:

  • 1st genu/Geniculate ganglion:
    • Landmark: Cochleariform process.
  • Runs horizontally on medial wall.
    • Above oval window
    • below LSC
  • 2nd genu:
    • Landmark: Pyramid
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Mastoid segment:

  • Vertical segment.
  • In mastoid bone.
  • Exits from stylomastoid foramen.
  • Iatrogenic facial palsy during mastoidectomy
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Extracranial route:

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  • Enters parotid gland.
  • Gives five terminal branches.

Branches

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Before 1st genu
Greater Petrosal Nerve
First branch
• Preganglionic parasympathetic

• from before 1st genu
↳ Joins with deep petrosal nerve
↳ Forms Nerve of pterygoid canal (Vidian nerve)
Lacrimation

# Affected if injury above 1st genu
# Great Superficial People make us cry
Branches before
Stylomastoid Foramen
Nerve to stapedius
At second genu
• If Affected →
Hyperacusis
Chorda Tympani
• from vertical segment
Functional nerve of submandibular ganglion
• Taste from anterior 2/3 of tongue
• Secretomotor fibers to submandibular and sublingual glands
• If Affected if
mastoid segment involved
Sensory auricular branch
Branches after
Stylomastoid Foramen
↳ To posterior belly of digastric
↳ To stylohyoid
↳ To auricular muscles
↳ To occipitalis
↳ To platysma
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Terminal Branches in Parotid Gland

  • Facial nerve divides into 5 branches in Patey's plane:
    • Temporal
    • Zygomatic
    • Buccal
      • Pierces buccinator muscle
    • Marginal mandibular
    • Cervical
  • Supplies muscles of facial expression
    • except LPS

Note:

Structure
Pierced by but not supplied by
Supplied by
Buccinator
Buccal N (branch of V3)
Buccal branch of facial nervemotor
Parotid
Facial nerve
Auriculotemporal N

NOTE: Referred Otalgia

Lesion Site
Nerve involved in referred pain
Oral lesions /dental caries
5th nerve (V3)
Oropharyngeal lesions / Tonsil
9th nerve (Glossopharyngeal)
Hypopharyngeal & Laryngeal lesions
10th nerve (Vagus)

Identification of Facial Nerve Trunk

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  • Cartilaginous Pointer
    • It is a sharp triangular cartilage of the pinna.
    • Facial nerve lies 1 cm deep, slightly anterior and inferior to this pointer.
    • Acts as a landmark — it “points” to the nerve.
  • Posterior Belly of Digastric Muscle
    • Upper border (anterior border) is used for tracing.
    • When traced posteriorly to its attachment at digastric groove,
      • → Facial nerve lies between posterior belly and styloid process.
  • Retrograde Dissection
    • Identification method by tracing from distal branch backward.

Topodiagnosis

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  • Identifying lesions via clinical tests.
  • Suprageniculate lesion:
    • Affects lacrimation, stapedial reflex, taste, motor fibers.
  • Infrageniculate lesion:
    • Affects stapedial reflex, taste, motor fibers.
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Clinical Points

  • Testing:
    • Ask patient to smileobserve angle of mouth deviation
  • Rule of 17:
    • CN VII lesion causes contralateral deviation of face
    • Right CN VII lesiondeviation to left
  • UMNL:
    • Contralateral lower face paralysis
  • LMNL:
    • Ipsilateral complete hemifacial paralysis
  • Facial colliculus lesion:
    • LMNL + ipsilateral paralysis

Facial Palsy causes summary

  • Most common cause:
    • Idiopathic > Traumatic
  • Iatrogenic facial palsy:
    • Occurs during mastoidectomy
    • Mastoid segment affected

Causes of B/L facial Nerve (diplegia):

Condition
Features
Sarcoidosis
Melkersson Rosenthal Syndrome
Triad:
• Recurrent facial nerve palsy
Swelling of lips
Fissured tongue

Melkerson → Rose koduthitt french kiss cheyth (lips - tongue)
GBS
Albumino-cytological dissociation
Earliest sign: Distal areflexia.
Bladder and bowel spared.
• Bilateral ascending symmetrical flaccid paralysis.
Brighton Criteria for GBS
Melkerson-Rosenthal syndrome
Melkerson-Rosenthal syndrome

Fractures of temporal bone

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  • Temple il uchaykk ponam (Uhrlich classification )
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Longitudinal fracture
Transverse fracture
Parallel to long axis of petrous bone
Perpendicular to long axis of petrous bone
More common
Less common
TM perforation ++
Not common
Less
High risk of facial nerve palsy
CHL ↑↑
SNHL risk ↑↑
CSF otorrhea common
Paradoxical CSF rhinorrhea
Less
Otic capsule involvement common

Common Features → CN 9 & 10

Col.
Function
SVA
Taste (project to nucleus solitarius)
From
posterior 1/3 of tongue (includes circumvallate papillae)
GVA
Visceral sensation
Posterior 1/3 of tongue
Soft palate
Pharynx
Posterior oral cavity
Carotid body, aortic body, SA node

Can cause
referred pain
SVE
Motor to stylopharyngeus muscle
From nucleus ambiguus
GVE
Parasympathetic to parotid
  • Both are mixed nerves
  • Involved in gag reflex
  • Contribute to pharyngeal plexus (with superior cervical ganglion)
  • Damage to nucleus ambigus:
    • Bulbar paralysis (except tongue)
    • Gag reflex lost

9th CN Clinical Points

  • Uvula test assesses CN IX
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Label - 2 → uvula

  • Damage:
    • Dysphagia, speech difficulty
    • Aspiration without voice change
    • Loss of gag reflex (with CN X)
  • Involved in Wallenberg syndrome

Branches

  • Tympanic nerve (Jacobson’s nerve):
    • Forms tympanic plexus
    • Gives rise to lesser petrosal nerve
  • Crosses stylopharyngeus,
    • enters pharynx between superior and middle constrictors

10th CN Clinical Points

  • Exits skull via jugular foramen (middle part)
  • SVA (Special Visceral Afferent):
    • Taste from epiglottis, lower pharynx
    • Via internal laryngeal nerve
    • Projects to nucleus solitarius
  • DamageGastroparesis
    • delayed stomach emptying
  • Recurrent laryngeal nerve injury:
    • Hoarseness
    • Dyspnea
    • Post-op dysphonia
    • Seen after thyroidectomy
  • Aspiration + voice change
  • Cardiac branches → cardiac plexus
  • Parasympathetic: cardioinhibitory
  • Part of Wallenberg syndrome

Relations

  • Runs in carotid sheath:
    • Between IJV (lateral) and CCA (medial)
    • Posterior in sheath
  • At aortic arch:
    • Posterior to phrenic nerve
    • Left vagus between left CCA and left subclavian
    • Right vagus lateral to brachiocephalic trunk