- Mnemonic:
- General science → save → gave
- GSE → General science → eye and tongue
- 3, 4 (GS → kollilla) → 6 (kollilla) → 12 clasees
- SVE → Save → Laugh and eat Na (NUcleus Ambigus)
- 0 → 7 → 9, 10, 11
- GVE → Gave → smooth action
- Edi (EW) → thuppi (SS, IS) → Vaninte door (Dorsal vagus) adach
- GVA, SVA → General Visceral sensations → Track (Nucleus Tractus solitarius) Viscera
- GSA → Giant SAAr → Big body (body wall)
- Mesayulla (Mesencephalic) Principal (Principal) with Spine (Spinal nuclei) → We Tried (Trigeminal)
- SSA → Sixth sense → All senses → vision, hearing, olfaction, balance
- But I have one to (1, 2 CN) 8 (8 CN) senses
- Column for 3rd CN
- GSE & GVE
- Column for 7, 9 ,10
- All except 1st and last
- NTS = Nine, Ten, Seven
- Ipsilateral Bulbar Palsy
- Injury to Nucleus Ambiguus (LMN Lesion)
- Features
- (tongue spared)
- Dysphagia
- Dysarthria
- Nasal speech
- Loss of GAG reflex
- High risk of aspiration
- Wasting & fasciculations of palate/pharynx
Region | Location | Structures | Nucleus |
Vision | Midbrain | Oculomotor Nerve, Superior Colliculus | Edinger–Westphal (EW) nucleus |
Pharynx & Larynx | Medulla | Cranial nerves 9, 10, 11 | Nucleus Ambiguus |
ㅤ | Full Form | ㅤ |
GVA | General Visceral Afferent | ㅤ |
SVA | Somatic Visceral Afferent | ㅤ |
GSA | General Somatic Afferent | Gen sensation of face |
SSA | Special Somatic Afferent | ㅤ |
ㅤ | Full Form | ㅤ | ㅤ |
GSE | General Somatic Efferent | ㅤ | ㅤ |
SVE | Special Visceral Efferent | Muscles of mastication | Save to eat |
GVE | General Visceral Efferent | ㅤ | ㅤ |
Nuclei | Full Form |
SSN | Superior Salivatory Nucleus |
ISN | Inferior Salivatory Nucleus |
NTS | Nucleus Tractus Solitarius |
Parasympathetic ganglion & Trigeminal Nuclei
- Everything is NCC
GVE | Nerve | Ganglion | Postganglionic fibers (branches of CN V) | Supply |
EW | 3 | Ciliary | ㅤ | Sphincter pupillae & Ciliaris muscle |
SSN | 7 → Via greater petrosal nerve | Pterygopalatine "Ganglion of Hay Fever" | Maxillary N (Zygomatic branch) | Lacrimal gland |
SSN | 7 → Via chorda tympani | Submandibular | Lingual N | Submandibular & Sublingual gland |
ISN | 9 → Via lesser petrosal fibers | Otic | Auriculotemporal N | Parotid |
Dorsal nucleus of X | 10 | ㅤ | ㅤ | Smooth muscles & glands of thorax & abdomen |
- Nerves whose general‐sensory fibers enter trigeminal nucleus
- Arnold’s nerve
- Glossopharyngeal nerve (proprioception from stylopharyngeus)
- Short ciliary nerves from ciliary ganglion supply:
- Sphincter pupillae - constriction of pupil.
- Ciliaris muscle - accommodation reflex.
- Important Point
- CN 7 pierces parotid gland
- But does NOT provide secretomotor supply to it
- Parasympathetic Outflow
- Cranio-sacral outflow
- Also Involves Sacral nerves (S2, S3, S4)
- Sympathetic outflow:
- Thoracolumbar (T1 to L2)
Trigeminal Nuclei → 3 Parts
a. Motor Nucleus of Trigeminal Nuclei (Pons)
- Supplies muscles of mastication
- SVE fibers (from 1st pharyngeal arch)
b. Sensory Nuclei
Part | Location | Function |
1. Mesencephalic | Midbrain | Proprioception from face ↳ Mediates jaw reflex, mastication, EOM, tongue ↳ Only site in CNS containing pseudo-unipolar neurons ↳ Contains primary sensory neuron cell bodies(unique in CNS) Dorsal coloumn? Mesa vach door thorannu |
2. Principal Sensory | Pons | Touch & pressure sensation from face Anterior STT? Principal Aunty |
3. Spinal Nucleus | Medulla | Pain & temperature from face Onion-skin pattern of facial sensory loss Lateral STT? Lateral spine |
- Pars caudalis = main pain nucleus of trigeminal system.
- Reflex intact even in trigeminal neuralgia
- d/t intact Mesencephalic nucleus
- Muscle responsible for jaw jerk reflex
- Masseter (afferent & efferent via trigeminal)
Trigeminothalamic Pathway
- 5th Nuclei Ganglion
- Trigeminal Lemniscus (1st Order Neuron)
- Thalamus (VPM Nucleus)
- Relays signals to the Sensory Cortex [3, 1, 2].
- Branches of Maxillary Nerve (V2) :
- Zygomaticotemporal Nerve
- Infraorbital Nerve
- Gives rise to alveolar branches
- Posterior Superior Alveolar Nerve
Alveolar Nerve Branches | Branch of | Supplies |
Posterior Superior Alveolar Nerve (PSAN) | Direct branch of Maxillary Nerve | Posterior maxillary teeth |
Middle Superior Alveolar Nerve (MSAN) | Branch of Infraorbital Nerve | Middle part of maxillary sinus and associated teeth |
Anterior Superior Alveolar Nerve (ASAN) | Branch of Infraorbital Nerve | Anterior maxillary teeth |
Sensory Tracts and Functions
- MTSL → Manage 3rd stage Labor
Sensory Tract | Carries C/L |
Lateral Lemniscus | Hearing sensation |
Spinal Lemniscus | Pain and temperature from body |
Trigeminal Lemniscus | Pain and temperature from face |
Medial Lemniscus (Anterior STT & DCT) | - Pressure & crude touch - Conscious proprioception - Fine touch - Vibration - Stereognosis |
CRANIAL NERVE RULES
Rule of 4
- Midbrain: CN
1, 2,3, 4
- Pons: CN 5, 6, 7, 8
- Medulla: CN 9, 10, 11, 12
Rule of 12
- Medial CN: 3, 4, 6, 12
- Affects tongue
Rule of S
- Side:
- Sensory → 5th CN, 7, 8 (pain, temp, etc.)
- Sympathetic → Horner’s
- Spinothalamic tract
- Spinocerebellar tract
Rule of M
- Medial:
- Motor CN - 3, 6, 12
- Corticospinal Tract (motor)
- Causes hemiplegia
- Medial lemniscus exception
- Not motor (dorsal column vibration, fine touch)
Reflexes
Rule of 17: Nerve Lesions and Deviations
Lesion: (Cranial Nerves 10 + 7 = 17)
- Deviation: Contralateral deviation (opposite side).
- Right X → Vagus
- Deviation of uvula to the left.
- Right VII → Facial
- Deviation of facial muscles to the left.
Lesion: (Cranial Nerves 12 + 5 = 17)
- Deviation: Ipsilateral deviation (same side).
- Left XII → Hypoglossal
- On protrusion, tongue deviates to the left.
- Left V → Trigeminal
- Deviation of jaw to the left.
Identification of Cranial Nerves
Identification of Cranial Nerves With Dura Mater Intact
Cranial Nerve - V
- Mixed Nerve
- V1 → Sensory
- V2 → Sensory
- V3 → mixed
- Divides into 3 branches
- Ophthalmic
- Maxillary
- Mandibular
- SVE → muscles of Mastication
- GSA → General sensation from face.
Ophthalmic Nerve (V1)
- Superior Orbital Fissure (SOF)
Frontal Nerve
- Supplies forehead skin.
- Branches:
- Supratrochlear nerve
- Supraorbital nerve
Nasociliary Nerve
- Branches:
- Anterior ethmoidal nerve
- Supplies dura mater of anterior cranial fossa.
- Goes to nasal cavity.
- Supplies ethmoidal and sphenoidal air sinus, nasal mucosa.
- Exits as external nasal branch.
- Supplies skin over the tip of the nose.
- Posterior ethmoidal nerve
Lacrimal Nerve
- Supplies the lacrimal gland.
Trigeminal Nerve
Branches from Trunk
- Nerve to medial pterygoid
- Supplies:
- Medial pterygoid (muscle of mastication)
- Tensor veli palatini
- Tensor tympani
- Only muscle of mastication supplied by trunk (others by anterior division)
- Nervus spinosus
- Passes through foramen spinosum
- Supplies dura mater along with middle meningeal artery (MMA)
- MMA + Nervus Spinosum = form major neurovascular supply to dura mater
Relations of otic ganglion
- Topographical relation with V₃
- Mandelu Otta
- No synapse occurs here
Relations | Muscle |
Anterior | Medial Pterygoid |
Posterior | MMA |
Lateral | V3 Nerve/ Mandibular N |
Medial | TVP |
Roof | Foramen ovale |
Topographic nerve
- Trigeminal nerve (V)
- All ganglia are topographically connected to trigeminal nerve
- Carries postganglionic fibres in parasympathetic pathway
Roots of Otic Ganglion
- Parasympathetic (secretomotor root)
- From glossopharyngeal nerve (CN IX) via lesser petrosal nerve
- Relay in otic ganglion
- Postganglionic fibers travel with auriculotemporal nerve (branch of V3)
- Auriculotemporal nerve (V3) pass through without relay
- Supply parotid gland
- Sympathetic root
- From plexus around middle meningeal artery
- postganglionic fibers from superior cervical ganglion
- Pass through ganglion without synapse
- Vasomotor to parotid gland
Mandibular Nerve (CN V₃)
- Mixed nerve
- Derived from 1st pharyngeal arch
- Largest and thickest branch of trigeminal nerve
- Root value: C₅, C₆, C₇, C₈, T₁
- Passes through foramen ovale (both sensory & motor components).
- All muscles supplied by V3 except
- Medial Pterygoid → Main trunk of 5th CN
- Mneumonic:
- Mandi (Mandibular) aytttulla oru auntie (Anterior ) always chew (mastication) → Was post (Posterior ) and sensitive (Sensory)
- She had a good aura (Auriculotemporal nerve) and good tongue (Lingual nerve) , but no lower teeth (Inferior alveolar nerve)
Divisions of Mandibular Nerve
- After passing through otic ganglion:
- Anterior division
- Posterior division
Anterior Division | (Motor>Sensory) |
Motor (SVE) | Muscle supplied |
Masseteric nerve | Masseter |
Deep temporal nerves | Temporalis |
Nerve to lateral pterygoid | Lateral pterygoid |
Sensory (GSA) | ㅤ |
Buccal Nerve | • Pierces buccinator muscle [Does NOT supply] Supplies: • Skin of cheek • Mucosa of cheek |
Posterior Division | (Mostly Sensory) |
Lingual Nerve | Sensory • GS to anterior 2/3 of tongue Parasympathetic Post ganglionic ↳ from submandibular ganglion ↳ to Submandibular & sublingual gland • M/c injured during Wharton’s/submandibular duct surgery. |
Inferior alveolar nerve | • Nerve to mylohyoid → Mylohyoid + Anterior belly of digastric • Mental nerve → Skin of chin |
NOTE
Structure | Pierced by but not supplied by | Supplied by |
Buccinator | Buccal N (branch of V3) | Buccal branch of facial nerve – motor |
Parotid | Facial nerve | Auriculotemporal N |
Inferior Alveolar artery
- Runs with the inferior alveolar nerve to supply the lower teeth.
- Gives off:
- Mental Artery: Exits through the mental foramen to supply the chin.
- Mylohyoid branch: Supplies the mylohyoid muscle.
- Mnemonic: Use lower teeth () when Myran (Mylohyoid A) becomes mental (Mental A)
Structures Piercing Buccinator
- Stenson's Duct / Parotid duct
- Buccal br. Of Mandibular (V3) NV
- Mucus glands of buccopharyngeal Fascia
NOTE
- Facial N supplies but does not pierce
Clinical Associations:
Trismus (Lockjaw)
- Silent trismus → Medial pterygoid
- Trismus while yawning/opening mouth → Lateral pterygoid
Frey’s Syndrome:
- Gustatory sweating.
- Parasympathetic fibers of Parotid gland (ATN)
- communicates with GAN (most common)
- Stimulus to ATN → sweating in parotid region
- Investigation: Starch iodine test.
- Sprinkle starch and Paint iodine
- ATN fuses with:
- Ettan (Atn) likes gan
- GAN > Buccal nerve > Lesser occipital nerve
- Mx:
- First line: Botox and anti-perspirants
- TOC: Tympanic neurectomy.
- Prevention:
- SCM flap/digastric muscle flap to cover parotid bed.
Facial Synkinesis
- Facial nerve anomalous regeneration
- Examples
- Crocodile tears (Bogorad syndrome):
- Facial N Injury before geniculate ganglion.
- Fibers anastomose with chorda tympani.
- Lacrimation when patient eats.
- Mouth retraction on eye closure
- orbicularis oculi aberrantly innervate orbicularis oris
Mandibular Foramen
- Transmits:
- Inferior alveolar nerve
- Inferior alveolar vessels
Clinical Testing – CN V₃ Motor
- Jaw deviation = test of mandibular nerve motor function
Muscles of Mastication (All by CN V₃)
Primary Muscles | Insertion | Notes |
Temporalis | • Coronoid process of mandible | • Elevation > Retraction |
Masseter | • Outer surface of ramus of mandible | • Elevation ↳ Strongest muscle of mastication ↳ Best muscle for elevation |
Medial Pterygoid | • Inner surface of ramus of mandible | • Elevation > Protrusion • Only muscle supplied by trunk of CN V₃ |
Lateral Pterygoid | • Capsule of TMJ | • Depression > Protrusion • Only depressing muscle of mastication |
- NOTE: Medial pterygoid plate : Doesn't give origin to pterygoid muscles.
- Protrusion
- Lateral > medial pterygoid
- Most apt answer is both
- Mnemonic: Teri (Both pterygoids) parayan jaw Protrude ()
- Opening the jaw/ depression of the mandible
- Lateral pterygoid muscle
- Remaining 3 muscles: Elevation of mandible
- Masseter > Temporalis & Medial pterygoid
- Side movement
- Alternate action of Lateral & Medial Pterygoids
Facial Nerve (Cranial Nerve 7)
- 7th cranial nerve.
Basic Features
- Mixed nerve
- Sensory root (nerve of Wrisberg).
- Motor root.
- Secretomotor root.
- Derived from the 2nd pharyngeal arch
- Exits from pons.
Nuclei
- Located in the pons
- Facial motor nucleus
- deep to the floor of the fourth ventricle
- Supranuclear palsy:
- UMN
- Lesion above pons.
- Forehead spared
- Innervation from bilateral cerebral cortex.
- Infranuclear palsy:
- LMN
- Lesion below pons.
Components and Functions
Col. | Nucleus | Function |
SVE | Facial motor nucleus in pons | Muscles from 2nd pharyngeal arch – facial expression |
GVE | SSN | Parasympathetic to submandibular, sublingual, and lacrimal glands |
SVA | NTS | Taste from anterior 2/3 of tongue (via chorda tympani) |
GVA | NTS | General visceral sensation |
GSA | Trigeminal sensory nucleus | Sensation from auricle, nasal, lacrimal regions |
Course and Exit
- Loops around abducent nucleus forming internal genu
- → elevation in floor of 4th ventricle = Facial colliculus
- Exits brainstem at pontomedullary junction
- Enters internal acoustic meatus
- Longest interosseous course
- Exits skull via stylomastoid foramen
Course has 3 parts:
- Intracranial.
- Intratemporal.
- Extracranial.
Intracranial route:
- Exits nucleus.
- Turns around 6th nerve nucleus → Facial Colliculus
- Enters internal auditory canal.
Intratemporal route:
- Longest portion.
- Runs in bony canal (Fallopian canal).
- Absent in 50% of population.
- Most common dehiscence site:
- horizontal part.
Segments:
Meatal Segment (8–10mm):
- In internal acoustic meatus.
- Falciform crest:
- vertical Y-shaped crest.
- Bills bar:
- crest of bone.
Quadrant of Internal Acoustic Meatus | Nerve Present |
Anterosuperior | Facial nerve |
Anteroinferior | Cochlear nerve |
Posterosuperior | Superior vestibular nerve |
Posteroinferior | Inferior vestibular nerve |
Labyrinthine segment:
- Travels above vestibule.
- Anterior: Cochlea.
- Posterior: Semicircular canals.
- Shortest and narrowest segment.
- Most prone to ischemia and edema [Bell’s Palsy]
Tympanic segment:
- 1st genu/Geniculate ganglion:
- Landmark: Cochleariform process.
- Runs horizontally on medial wall.
- Above oval window
- below LSC
- 2nd genu:
- Landmark: Pyramid
Mastoid segment:
- Vertical segment.
- In mastoid bone.
- Exits from stylomastoid foramen.
- Iatrogenic facial palsy during mastoidectomy
Extracranial route:
- Enters parotid gland.
- Gives five terminal branches.
Branches
Before 1st genu | ㅤ |
↳ Greater Petrosal Nerve | • First branch • Preganglionic parasympathetic • from before 1st genu ↳ Joins with deep petrosal nerve ↳ Forms Nerve of pterygoid canal (Vidian nerve) ↳ Lacrimation # Affected if injury above 1st genu # Great Superficial People make us cry |
Branches before Stylomastoid Foramen | ㅤ |
↳ Nerve to stapedius | • At second genu • If Affected → Hyperacusis |
↳ Chorda Tympani | • from vertical segment • Functional nerve of submandibular ganglion • Taste from anterior 2/3 of tongue • Secretomotor fibers to submandibular and sublingual glands • If Affected if mastoid segment involved |
↳ Sensory auricular branch | ㅤ |
Branches after Stylomastoid Foramen | ㅤ |
↳ To posterior belly of digastric ↳ To stylohyoid ↳ To auricular muscles ↳ To occipitalis ↳ To platysma | ㅤ |
Terminal Branches in Parotid Gland
- Facial nerve divides into 5 branches in Patey's plane:
- Temporal
- Zygomatic
- Buccal
- Pierces buccinator muscle
- Marginal mandibular
- Cervical
- Supplies muscles of facial expression
- except LPS
Note:
Structure | Pierced by but not supplied by | Supplied by |
Buccinator | Buccal N (branch of V3) | Buccal branch of facial nerve – motor |
Parotid | Facial nerve | Auriculotemporal N |
Identification of Facial Nerve Trunk
- Cartilaginous Pointer
- It is a sharp triangular cartilage of the pinna.
- Facial nerve lies 1 cm deep, slightly anterior and inferior to this pointer.
- Acts as a landmark — it “points” to the nerve.
- Posterior Belly of Digastric Muscle
- Upper border (anterior border) is used for tracing.
- When traced posteriorly to its attachment at digastric groove,
→ Facial nerve lies between posterior belly and styloid process.
- Retrograde Dissection
- Identification method by tracing from distal branch backward.
Topodiagnosis
- Identifying lesions via clinical tests.
- Suprageniculate lesion:
- Affects lacrimation, stapedial reflex, taste, motor fibers.
- Infrageniculate lesion:
- Affects stapedial reflex, taste, motor fibers.
Clinical Points
- Testing:
- Ask patient to smile → observe angle of mouth deviation
- Rule of 17:
- CN VII lesion causes contralateral deviation of face
- Right CN VII lesion → deviation to left
- UMNL:
- Contralateral lower face paralysis
- LMNL:
- Ipsilateral complete hemifacial paralysis
- Facial colliculus lesion:
- LMNL + ipsilateral paralysis
Facial Palsy causes summary
- Most common cause:
- Idiopathic > Traumatic
- Iatrogenic facial palsy:
- Occurs during mastoidectomy
- Mastoid segment affected
Causes of B/L facial Nerve (diplegia):
Condition | Features |
Sarcoidosis | ㅤ |
Melkersson Rosenthal Syndrome | Triad: • Recurrent facial nerve palsy • Swelling of lips • Fissured tongue Melkerson → Rose koduthitt french kiss cheyth (lips - tongue) |
GBS | • Albumino-cytological dissociation • Earliest sign: Distal areflexia. • Bladder and bowel spared. • Bilateral ascending symmetrical flaccid paralysis. • Brighton Criteria for GBS |
Fractures of temporal bone
- Temple il uchaykk ponam (Uhrlich classification )
Longitudinal fracture | Transverse fracture |
Parallel to long axis of petrous bone | Perpendicular to long axis of petrous bone |
More common | Less common |
TM perforation ++ | Not common |
Less | High risk of facial nerve palsy |
CHL ↑↑ | SNHL risk ↑↑ |
CSF otorrhea common | Paradoxical CSF rhinorrhea |
Less | Otic capsule involvement common |
Common Features → CN 9 & 10
Col. | Function |
SVA | Taste (project to nucleus solitarius) From posterior 1/3 of tongue (includes circumvallate papillae) |
GVA | Visceral sensation • Posterior 1/3 of tongue • Soft palate • Pharynx • Posterior oral cavity • Carotid body, aortic body, SA node Can cause referred pain |
SVE | Motor to stylopharyngeus muscle |
GVE | Parasympathetic to parotid |
- Both are mixed nerves
- Involved in gag reflex
- Contribute to pharyngeal plexus (with superior cervical ganglion)
- Damage to nucleus ambigus:
- Bulbar paralysis (except tongue)
- Gag reflex lost
9th CN Clinical Points
- Uvula test assesses CN IX
Branches
- Tympanic nerve (Jacobson’s nerve):
- Forms tympanic plexus
- Gives rise to lesser petrosal nerve
- Crosses stylopharyngeus,
- enters pharynx between superior and middle constrictors
10th CN Clinical Points
- Exits skull via jugular foramen (middle part)
- SVA (Special Visceral Afferent):
- Taste from epiglottis, lower pharynx
- Via internal laryngeal nerve
- Projects to nucleus solitarius
- Damage → Gastroparesis
- delayed stomach emptying
- Recurrent laryngeal nerve injury:
- Hoarseness
- Dyspnea
- Post-op dysphonia
- Seen after thyroidectomy
- Aspiration + voice change
- Cardiac branches → cardiac plexus
- Parasympathetic: cardioinhibitory
- Part of Wallenberg syndrome
Relations
- Runs in carotid sheath:
- Between IJV (lateral) and CCA (medial)
- Posterior in sheath
- At aortic arch:
- Posterior to phrenic nerve
- Left vagus between left CCA and left subclavian
- Right vagus lateral to brachiocephalic trunk